Mitochondrial Genetics and Human Systemic Hypertension
نویسندگان
چکیده
منابع مشابه
Mitochondrial genetics and human systemic hypertension.
Evolution of biological processes is fascinating and more so the evolutionary reduction of mitochondrial genome. A proteobacterium that invaded the nucleus-containing host cell 1.5 billion years ago, as would the endosymbiotic model surmises,1 ended up enslaved and yet became the essence of life of the invaded cell. And, if so, the invader could not have had a genome that was comprised of only ...
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EH (essential hypertension) is a major public health problem in many countries due to its high prevalence and its association with coronary heart disease, stroke, renal disease, peripheral vascular disease and other disorders. Epidemiological studies have demonstrated that EH is heritable. Owing to the fact that blood pressure is controlled by cardiac output and total peripheral resistance, man...
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Results We used a candidate gene association study of common variants across the NPPA-NPPB locus to identify genetic variants that influence atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) [1]. The minor alleles of three noncoding SNPs rs5068 (MAF 0.06), rs198358 (MAF 0.19) and rs632793 (MAF 0.38) were associated with higher ANP (+0.42 SD p=8x10-70; +0.20 p=8x10-30; +0.08 ...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2011
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.111.242768